Advanced Pharmacometrics

Clinical Pharmacology

• Rational Dose Prediction
• Absorption Processes and Half-life
• Clearance
• Volume of Distribution
• Drug Metabolism
• Pharmacogenetics and Drug Interactions
• Pharmacodynamic Principles and The Time Course of Immediate Drug Effect
• Delayed and Cumulative Drug Effects
• Ligand Binding and Stimulus-Response
• Loading and Maintenance Doses
• Disease Progression
• Regulatory Applications
• Quantitative Rules for Using Variability for Dosing
• Clinical Trial Simulation: Washout and Delayed Start
• Clinical Trial Simulation and Analysis
• Dosing in children - How to Reach the Target Effect
• Time Course of Placebo and Anti-depressant Effect

Methodology

• Model Evaluation
• Input Output Models
• PKPD Modelling with NONMEM 7 and Monolix 31SR2
• NONMEM and PREDPP
• Confidence Intervals
• Randomization Test
• NONMEM and Differential Equations
• Absorption Processes
• Rate Dependent Extraction
• Absorption Process Files
• Transit Delay Files
• Dropout Models
• Effects of Informative Dropouts on the Design and Evaluation of Clinical Trials
• Time to Event Analysis / Modelling Likelihoods
• Time to Event Diagnostics
• VPC Tutorial
• Censored Observations
• Clinical Trial Simulation using NONMEM
• Hands-on Clinical Trial Simulation using NONMEM7.2
• Clinical Trial Simulation using the Pharsight Trial Simulator