NextDose: A web-based Bayesian dose forecasting tool

Last updated 13 December 2020

Target Types

 

Type

NextDose Target Type

Note

Steady state average concentration

Css avg

 

Steady state concentration at user selected time after dose

Css8h

Csstrough

Drug specific time

Time of trough concentration determined by user choice of target dosing interval

Area under the curve from 0 to infinity

AUCss 0-inf

 

Steady state area under the curve over target dosing interval

AUCssDI

Dosing interval (DI) determined by user choice of target dosing interval

Steady state area under the curve over specified interval

AUCss24

AUC over 24 h dosing interval

Steady state average biomarker

INR

 

 

Some targets may be scaled by the minimum inhibitory concentration (MIC). In that case the target for scaled concentrations has no units and the target for scaled AUCs has the unit of time (e.g. h).