Faculty of Medical and Health Sciences
Department of Pharmacology & Clinical Pharmacology, University of Auckland
Faculty of Medical and Health Sciences
Department of Pharmacology & Clinical Pharmacology, University of Auckland

Projects and research

Principal investigator

Prof Nick Holford
Professor
Pharmacology & Clinical Pharmacology
Room: 503-229
Phone: +64 9 373 7599 ext 86730
Email: n.holford@auckland.ac.nz

Research interests include:

Clinical trial simulation

A rational approach to the clinical phases of drug development is based on the application of pharmacokinetic and pharmacodynamic principles. The use of mathematical models to describe and explain human responses to new drugs is being explored using mixed effect nonlinear regression and clinical trial simulation. Current work is exploring methods for the optimal design of clinical trials.

Disease progress and drug action

Clinical pharmacology expresses the combined knowledge of disease and how drugs affect it. Attention is turning towards understanding how drugs affect the long-term progression of disease. Dr Holford is engaged in studies of Parkinson's Disease and Alzheimer's Disease, osteoporosis and depression which describe both the effects of drugs and the natural progression of the disease over time.

Paediatric dosing

History of Pharmacometrics