Professor Nick Holford
Department of Pharmacology & Clinical Pharmacology, FMHS, University of Auckland Professor Nick Holford
Department of Pharmacology & Clinical Pharmacology, FMHS, University of Auckland

MEDSCI 722 workshop timetable

Workshops are held on Wednesdays from 11:00 am - 1:00 pm in room 502-003

Date Session Topic Resources Teaching staff
20 Jul 1 Introduction to course/revision
  • Clearance
    		•  NH
  • Volume
    		•
  • Absorption & half-life
    		•
  • Drug metabolism
    		•
  • Pharmacogenetics & drug interactions
    		•
  • Immediate drug effects
    		•
  • Delayed drug effects
    		•
  • Cumulative drug effects
    		•
    27 Jul 2 Drugs in the neonate & child
  • Drugs in the neonate & child
    		•  BA
  • Size and Maturity (PDF, 411 KB)
    		•
    3 Aug 3 PKPD variability
  • PKPD variability
    		•  NH
  • Target concentration intervention and between occasion variability
    		•
  • Population PKPD
    		•
    10 Aug 4 Predicting and preventing adverse drug reactions and interactions
  • Predicting and preventing adverse drug reactions and interactions
    		•  MT
    17 Aug 5 Disease progression and drug action
  • Disease progression
    		•  NH
  • Disease Progress Models (PDF, 333 KB)
    		•
    24 Aug 6 Class effects
  • Class effects
    		•  NH/DW
  • Class effects article
    		•
    Mid-semester break 29 Aug - 10 Sep
    14 Sep 7 Drug disposition in pregnancy
  • Drug disposition in pregnancy
    		•  AP
    21 Sep 8 Drug Literature Evaluation
  • Drug literature evaluation
  • Notes
    		•  TS
    28 Sep 9 Clinical trials; design, and analysis
  • Clinical trials; design, and analysis
    		•  NH
    Video cartoon :-)
  • Clinical drug development
    		•
  • Clinical measurement
    		•
    5 Oct 10 Coursework presentations NH
    12 Oct 11 Coursework presentations NH
    19 Oct 12 Clinical pharmacology review NH
    TBA Final Exam To be announced

    Teaching staff: NH - Nick Holford; BA - Brian Anderson; AP - Anna Ponnampalam; MT - Malcolm Tingle; TS - Trevor Speight; DW - David Woolner

    Suggested Reading Materials

    1. Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE. Developmental pharmacology--drug disposition, action, and therapy in infants and children. N Engl J Med 2003; 349:1157-67
    2. Koren G. Chapter 60. Special aspects of perinatal and pediatric pharmacology. In Basic & Clinical Pharmacology ed Katzang BG, Appleton & Lange
    3. Anderson BJ, Holford NHG. Mechanism based concepts of size and maturity in pharmacokinetics. Annual Review of Pharmacology and Toxicology 2008; 48: 303-32
    4. Anderson BJ, Holford NHG. Mechanistic basis of using body size and maturation to predict clearance in humans. Drug Metab Pharmacokinet 2009; 24 (1): 25-36
    5. Anderson BJ, Meakin GH.  Scaling for size; some implications for paediatric anaesthesia dosing.  Paediatr Anaesthesia 2002; 12: 205-219
    6. Bartelink IH, Rademaker CM, Schobben AF, van den Anker JN. Guidelines on paediatric dosing on the basis of developmental physiology and pharmacokinetic considerations. Clin Pharmacokinet 2006; 45: 1077-1097
    7. Holford NH . Dosing in children. Clin Pharm Ther 2010;87:367-70

    Prof Nick Holford
    Professor
    Pharmacology & Clinical Pharmacology
    Room: 503-229
    Phone: +64 9 373 7599 ext 86730
    Email: n.holford@auckland.ac.nz

    Assoc Prof Brian Anderson
    Clinical Associate Professor
    Anaesthesiology
    Email: briana@adhb.govt.nz

    Dr Anna Ponnampalam
    Postdoctoral Research Fellow
    Liggins Institute
    Room: 529-119
    Phone: +64 9 373 7599 ext 82115
    Email: a.ponnampalam@auckland.ac.nz

    Dr Malcolm Tingle
    Associate Professor
    Pharmacology & Clinical Pharmacology
    Room: 503-295
    Phone: +64 9 373 7599 ext 84949; 9234949
    Email: m.tingle@auckland.ac.nz

    Dr David Woolner
    Senior Lecturer, Honorary
    Pharmacology & Clinical Pharmacology
    Email: dwoolner@xtra.co.nz