Advanced Pharmacometrics
Clinical Pharmacology
- Clearance
- Volume of distribution
- Absorption and half-life
- Drug metabolism
- Variability due to genetic differences
- Variability due to environmental differences
- Immediate time course of drug effect
- Delayed time course of drug effect
- Target concentration intervention
- Poisons and poisoning
- Drug development and clinical trials
- Clinical pharmacology research for medical students
- Respiratory Pharmacology
- Rational Dose Prediction
- Ligand Binding and Stimulus-Response
- Digoxin & Theophylline Loading and Maintenance Doses
- Theophylline Loading & Maintenance Dose Question
- Quantitative Pharmacology: Birth,maturation,adulthood
- PKPD Changes with Age
- Disease Progress, Drug Action, Placebo.pdf
- Clinical Pharmacology = Disease Progress + Drug Action
- Regulatory Applications of Clinical Pharmacology = Disease Progress + Drug Action
- Disease Progress and Drug Action
- Target Concentration Intervention - Can We Hit the Targets?
- Busulfan Target Concentration Intervention
- Mycophenolate Target Concentration Intervention
- TDM is dead! Long live TCI!
- Clinical Drug Development
- Clinical Trials and Analysis
- Quantitative Rules for Using Variability for Dosing
- Clinical Trial Simulation: Washout and Delayed Start
- Clinical Trial Simulation and Analysis
- Dosing in children - How to Reach the Target Effect
- Time Course of Placebo and Anti-depressant Effect
- Tips and Traps in Pediatric PKPD
- Gemcitabine Tumour Size and Wang-Claret Survival Model
- Regulatory Applications
- Placebo Response
- Busulfan Pharmacokinetics - an Integrated Size and Age Approach to support Target Concentration Intervention
- Busulfan FirstDose Calculators
- Busulfan Target Concentration Intervention Audit and Model Evaluation
- Using Normal Fat Mass to Account for Body Size and Composition
- Using Normal Fat Mass to Account for Body Size and Composition (Narrated 33MB)
- Why Clearance is my Religion
- Babies, Children, Adults - Integrated Dosing
- Parkinson's disease, disease progress, interpretation of ELLDOPA
- Nomogram to NextDose
- Clever models or dumb spreadsheets to drive policy change (Paolo Denti)
- PAGE-Physiological-Approach-to-Renal-Clearance
Methodology
- Input Output Models
- Principles of Covariate Modelling
- Model Evaluation
- Visual Predictive Checks
- NONMEM Installation
- NONMEM and PREDPP
- Confidence Intervals
- Randomization Test
- NONMEM and Differential Equations
- Absorption Processes
- PKPD Modelling with NONMEM 7 and Monolix 31SR2
- PKPD Modelling with NONMEM 730
- Time to Event Principles for Pharmacometricians
- Repeated Time to Event Principles
- Time to Event Implementation
- Time to Event Diagnostics
- Effects of Informative Dropouts on the Design and Evaluation of Clinical Trials
- Modelling Informative Dropout using NONMEM
- Censored Observations
- Clinical Trial Simulation using NONMEM
- Hands-on Clinical Trial Simulation using NONMEM7.2
- Clinical Trial Simulation using the Pharsight Trial Simulator
- Simulation in Drug Development Good Practices