Last updated 14 December 2023
NextDose Doses and Observations window is used to enter doses and individual
observations such as weight. Observation types such as weight are associated
with a date and time so that time varying changes in these observations may be
used by the NextDose model.
also observation types that are not time sensitive. They can be associated with
any date and time and have an effect across the full time sensitive dosing and
The AUC Occ
observation calculates the area under the curve (AUC) after each dose until the
time of the next dose (a dosing occasion) based on the predicted individual
concentration shown in the graph on the Results page. The AUC following the
last dose is calculated until the end of the predicted individual concentration
display. The measurement box should be set to a value of 1 to activate this
The AUC associated with for each dose and associated individual CL/F value is displayed as AUC inf alongside the AUC occ value. The ratio of AUC occ to AUC inf gives an indication of how close AUC occ is approaching the steady state AUC during the dosing occasion.
The AUC T1 observation calculates the area under the curve (AUC) of the predicted individual concentration from the AUC starting time (h) entered in the measured value box. The time in hours is counted from the time of the first dose in the Doses and Observations window. If this is set to 0 h, this will measure from the time the first dose, either an oral dose, an IV bolus dose or start of an IV infusion dose. If the AUC starting time is set to 24 h then it will measure from 24 hours after the time of the first dose. Note that the date and time associated with the “AUC T1” observation is not used in calculating the AUC.
The AUC T2 observation calculates AUC from the AUC starting time in AUC T1 and ending at the user specified time (h) entered in the AUC T2 measured value box. This should be set to a value greater than the AUC T1, otherwise no value for AUC is generated. Note that the date and time associated with the “AUC T2” observation is not used in calculating the AUC.
AUC occ to see the times of doses as a guide for selection of AUC T1 and AUC
T2. AUC T1 with AUC T2 takes precedence over AUC occ. Delete or ignore the AUC
T1 and T2 observation types in order to use AUC occ.
AUC estimates calculated from the predicted individual concentration time
course use a simple trapezoidal integration method with an error of around 1%.
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reserved | Developed by Sam Holford & Nick Holford 2012-2023