Faculty of Medical and Health Sciences
Department of Pharmacology & Clinical Pharmacology, University of Auckland
Faculty of Medical and Health Sciences
Department of Pharmacology & Clinical Pharmacology, University of Auckland

Analysis of literature data

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Overview

As the science of pharmacometrics has evolved new methods and ideas can be applied to old problems. The clinical pharmacology literature contains many examples of studies which present all the data required for a model based pharmacometric analysis but frequently the data is presented without formal modelling. You are encouraged to explore the literature for a clinical pharmacology study that you can model using both simulation and model building/parameter estimation.

OBJECTIVES

1. To create and use a model by analysing literature data

2. To be able to make an oral presentation on a pharmacometric analysis

Assignment

1. Find a clinical pharmacology study which provides sufficiently detailed results so that you can analyse the data using a model.

You may find observations in a table or may need to read them from a graph.

2. Use the modelling tools you have applied in earlier assignments to simulate the data in the clinical pharmacology study.

3. Build a model to describe the data and estimate its parameters.

4. Discuss your results in relation to the literature report.

Your written assignment should form the basis of an oral presentation (appx 10 minutes) which you will be asked to give to the Pharmacometrics class.