Changes

Last updated 17 June 2024

NextDose is a web-based Bayesian dose forecasting tool.

See GitHub Readme for further details of version changes.

17-Jun-2024: v 2.1.01: AUC occ and AUC_T1 and AUC_T2 may be used at the same time. AUC_T1 and AUC_T2 may be used, but not AUC occ, with a cumulative AUC target.

31-May-2024: v 2.0.11: Bug fix for AUC_T1 and AUC_T2 when value is specified ".".

24-May-2024: v 2.0.10: Bug fix for voriconazole target summary with CssAvg target.

28-Apr-2024: v 2.0.09: May use observation date and time with "." for value or enter values in hours since start of concentration predictions. Multiple AUC_T1_T2 observations have been enabled.

18-Apr-2024: v 2.0.08: Bug fix for time after dose target.

14-Apr-2024: v 2.0.07: Bug fix for repeated steady state dose records. Bug fix when steady state actual dose interval is not the same as the target dose interval.

08-Mar-2024: v 2.0.06: Predictions limited for early events when long follow up exceeds prediction records limit.

06-Feb-2024: v 2.0.05: Bug fix for user entered commas entered instead of decimal points for numerical values. Identification of user who ran the Results calculation to help teams working on NextDose. Increased default for run execution time to reduce timeout errors. Added AUC occ observation type for busulfan to allow more detailed reporting when the target is not a cumulative AUC. Changed significant number of decimal digits so they are consistent across calculated output values.

05-Jan-2024: v 2.0.04: Bug fix for AUC_T1 and AUC_T2

14-Dec-2023: v 2.0.03: Clearance values use consistent numerical format.

09-Nov-2023: v 2.0.02: Bug fix to show last cumulative AUC dose and activation of Show More for cumulative AUC target.

05-Nov-2023: v 2.0.01: Improved calculation of doses to achieve a cumulative AUC target.

01-Nov-2023: v 2.0.00: AUC observation types.

17-Oct-2023: v 1.9.16: Smaller time intervals for tacrolimus for better graph predictions with many doses.

25-Sep-2023: v 1.9.15: Bug fix for user specified dosing interval in gentamicin, tobramycin, amikacin, vancomycin models.

09-Jul-2023: v 1.9.14: Updated versions of gentamicin, tobramycin, amikacin, vancomycin models.

05-May-2023: v 1.9.13: Results page shows target AUC with standard integration interval rather than user specified dosing interval.

28-Apr-2023: v 1.9.12: Bug fix for tacrolimus time after transplant when non-SS doses start more than 3 days after transplant.

24-Feb-2023: v 1.9.11: Time course on graphs using Repeat Doses improved.

20-Feb-2023: v 1.9.10: Changes to text describing proposed dose with cumulative AUC target.

29-Nov-2022: v 1.9.9: Print report infusion duration and time-since-dose formatting changed.

17-Nov-2022: v 1.9.8: Busulfan 3-day cumulative AUC target option added.

29-Sep-2022: v 1.9.7: Bug fix for linezolid error when serum creatinine not supplied.

27-Sep-2022: v 1.9.6: Bug fix for FirstDose mode with user defined PO dose and default IV route.

26-Sep-2022: v 1.9.5: Medicines now list alphabetically in add medicine drop down.

09-Jul-2022: v 1.9.4: Bug fix to enable clearer warning when cum AUC exceeds target.

17-May-2022: v 1.9.3: Bug fix corrected proposed doses not matching Bayesian average dose.

01-May-2022: v 1.9.2: Improved display of user defined cumulative AUC target. "Show more" observation type implemented for cumulative AUC target.

28-Apr-2022: v 1.9.1: Bug fix for proposed IV and PO doses when PO doses administered before IV doses.

27-Apr-2022: v 1.9.0: Improved display of user defined AUC/MIC target.

25-Apr-2022: Bug fix for cumulative AUC proposed dose for consistency with choice of dose prediction method.

29-Mar-2022: Linezolid additional platelet units option (10^9/L); improved results plot showing baseline platelet measurement.

24-Mar-2022: Ganciclovir (IV) and valganciclovir (PO) model released for NextDose.

06-Feb-2022: Update: Fat free mass prediction method for neonates, infants and children improved especially for neonates. Fix: Improved description of remaining doses for cumulative AUC target.

16-Jul-2021: Bug fix for 'Actual Dose' display on Results page when haematocrit is used to standardize predictions.

25-May-2021: Bug fix when 'what if' calculation used with cumulative AUC target. Bug fix when end infusion time specified before dose start time.

18-Mar-2021: Posaconazole model released for NextDose. Trough target option added to prediction of FirstDose.

24-Dec-2020: Single dose infusion duration was incorrect if it followed repeated dose infusions with a different dosing interval. This has been corrected.

12-Dec-2020: Height was not imputed unless at least one dose given. This restriction has been removed.

11-Dec-2020: TAD target may use target dosing interval for trough time (CssTroughDI)

19-Nov-2020: Feature removal request: MIC observation type removed from gentamicin, amikacin, vancomycin.

11-Nov-2020: Bug occurring with repeated infusions with different infusion durations has been fixed.

24-Oct-2020: Tobramycin models released for NextDose. The tobramycin models and parameters are based on those for gentamicin because the PK is very similar for both drugs.

22-Sep-2020: Genotype information for CYP4F2 and VKORC1 on Patient Details page expanded to specify the rs genotype identifier.

09-Sep-2020: Additional target type options with fixed AUC integration intervals. The busulfan option is for AUC over 4 days. The vancomycin option if for a steady state AUC over 48 h. These options make it simpler to use recommended AUC targets with these integration intervals.

08-Aug-2020: Dabigatran models released for NextDose. Algorithm improved for proposed dose calculation when there are both IV and PO routes.

07-Jul-2020: Repeated dose algorithm re-written to improve occasion detection and overlapping dose implementation. Equivalent Css average target shown when AUC target requested. Warning shown for tacrolimus if day of transplant not supplied.

01-Jun-2020: Patient Details used to specify Actual, Test or Demo type. Instances (date-time) list uses colour to distinguish Results calculated with Actual patient data or What If (simulation) data or changed data before Results. Results format changed using colours and tables. Individual PKPD and covariate variables displayed for each occasion.

16-Apr-2020: Hydroxychloroquine whole blood concentration model added based on Carmichael 2003 population PK analysis.

11-Feb-2020: Free text entry boxes for Patient Details and Comments on the Printable Results Report have been made more flexible to allow users to record more information.

01-Jun-2019: Schwartz creatinine clearance changed to use gestational age < 40 instead of post-mentstrual age < 40 weeks.

04-Apr-2019: Sumpter method for prediction of fat free mass fraction of adult value capped at 1 for premature boys.

11-Mar-2019: CYP3A5 genotype variants added as observation type for tacrolimus.

03-Mar-2019: Albumin added as observation type for mycophenolate.

12-Feb-2019: Target conc for mycophenolate changed from 40 to 50 mcg/L unbound.

28-Jan-2019: The home pages for NextDose and dev.NextDose have been simplified. Information about NextDose that was on the home pages is now accessible through this web.

27-Jan-2019: Five new medicine models have been tested using dev.NextDose (gentamicin, amikacin, vancomycin, caffeine and mycophenolate). These models are now available for use with NextDose.

29-Jul-2018: Target dose predictions are now based on covariates (fixed effects) at the end of dosing intervals rather than the start. This should give better predictions when covariates change during a dosing interval such as the empirical time varying clearance of busulfan.

29-Jul-2018: Choice between using between occasion variability (BOV) with between subject variability (BSV) or BSV alone for dose prediction. See Dose Prediction.